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1 Exit all running applications, disable the screen saver 2 From the Start menu, select Programs | Accessories | System Tools | Disk Defragmenter in Windows 9x/2000 or Start| All Programs | Accessories | System | Disk Defragmenter in Windows XP 3 You will be presented with a Select Drive dialog box Select the appropriate hard drive from the drop-down menu, then click OK 4 The Defragmenter utility will begin You can view the cluster-by-cluster details of the operation by clicking the Show Details button

Acknowledging Alerts To acknowledge an alert, use the ALTER command and update the examinedBy attribute This action will notify other administrators that the alert has been acknowledged and worked upon The ALTER ALERTHISTORY command allows you to modify either individual alerts (by providing the alert identifier) or all alerts in the system These examples illustrate the use of this command:

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ADAMS RD, KAKULAS BA, SAMAHA FA: A myopathy with cellular inclusions Trans Am Neurol Assoc 90:213, 1965 AMATO AA, GRIGGS RC: Unicorns, dragons, polymyositis, and other mythological beasts Neurology 61:288, 2003 ANTONY JH, PROCOPIS PG, OUVRIER RA: Benign acute childhood myositis Neurology 29:1068, 1979 ARGOV Z, TIRAM E, EISENBERG GI, et al: Various types of hereditary inclusion body myopathies map to chromosome 9p1-q1 Ann Neurol 41: 548, 1997 ASKANAS V, ENGEL WK, ALVAREZ RB: Enhanced detection of Congored-positive amyloid deposits in muscle bers of inclusion body myositis and brain of Alzheimer s disease using uorescence technique Neurology 43:1265, 1993 BANKER BQ: Dermatomyositis of childhood: Ultrastructural alterations of muscle and intramuscular blood vessels J Neuropathol Exp Neurol 34: 46, 1975 BANKER BQ: Other in ammatory myopathies, in Engel AG, Franzini-Armstrong C (eds): Myology, 2nd ed New York, McGraw-Hill, 1994, pp 1461 1486 BANKER BQ: Parasitic myositis, in Engel AG, Franzini-Armstrong C (eds): Myology, 3rd ed New York, McGraw-Hill, 2004, pp 1419 1444 BANKER BQ, VICTOR M: Dermatomyositis (systemic angiopathy) of childhood Medicine 45:261, 1966 BAROHN RJ, AMATO AA, SAHENK Z, et al: Inclusion body myositis: Explanation for poor response to immunosuppressive therapy Neurology 45:1302, 1995 BASSEZ G, AUTHIER FJ, LECHAT-ZAKMAN E, et al: In ammatory myopathy with abundant macrophages (IMAM) A condition sharing sim-

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ilarities with cytophagic histiocytic panniculitis and distinct from macrophagic myofasciitis J Neuropath Exp Neurol 62:464, 2003 BROUWER R, HENSGSTMAN GJD, EGBERTS WV, et al: Autoantibody pro les in the sera of European patients with myositis Ann Rheum Dis 60:116, 2001 BUCHBINDER R, HILL CL: Malignancy in patients with in amatory myopathy Curr Rheumatol Rep 4:415, 2002 COLE AJ, KUZNIESKY R, KARPATI G, et al: Familial myopathy with changes resembling inclusion body myositis and periventricular leukoencephalopathy Brain 111:1025, 1988 CUMMING WJK, WEISER R, TEOH R, et al: Localized nodular myositis: A clinical and pathological variant of polymyositis Q J Med 46:531, 1977 DALAKAS MC: Intravenous immune globulin therapy for neurological diseases Ann Neurol 126:721,1997 DALAKAS MC, HOHLFELD R: Polymyositis and dermatomyositis Lancet 362:971, 2003 DALAKAS MC, ILLA I, PEZESHKPOUR GH, et al: Mitochondrial myopathy caused by long-term zidovudine therapy N Engl J Med 322:1098, 1990 DEVERE R, BRADLEY WG: Polymyositis, its presentation, morbidity and mortality Brain 98:637, 1975 DION E, CHERIN P, PAYAN C, et al: Magnetic resonance imaging criteria for distinguishing between inclusion body myositis and polymyositis J Rheumatol 29:1897, 2000 DUA HS, SMITH FW, SINGH AK, Forrester JV: Diagnosis of orbital myositis by nuclear magnetic resonance imaging Br J Ophthalmol 71:54, 1987 EISENBERG I, AVIDAN N, POTIKHA T, et al: The UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene is mutated in recessive hereditary inclusion body myopathy Nat Genet 29:83, 2001 EMSLIE-SMITH AM, MAYENO AN, NAKANO S, et al: 1,1-Ethylidenebis[tryptophan] induces pathologic alterations in muscle similar to those observed in the eosinophilia-myalgia syndrome Neurology 44:2390, 1994 ENGEL AG, ARAHATA K: Mononuclear cells in myopathies: Quantitation of functionally distinct subsets, recognition of antigen-speci c cell-mediated cytotoxicity in some diseases and implications for the pathogenesis of the different in ammatory myopathies Hum Pathol 17:704, 1986 ENGEL AG, EMSLIE-SMITH AM: In ammatory myopathies Curr Opin Neurol Neurosurg 2:695, 1989 ENGEL AG, HOHLFELD R, BANKER BQ: The polymyositis and dermatomyositis syndromes, in Engel AG, Franzini-Armstrong C (eds): Myology, 3rd ed New York, McGraw-Hill, 2004, pp 1321 1366 GAMBOA ET, EASTWOOD AB, HAYS AP, et al: Isolation of in uenza virus from muscle in myoglobinuric polymyositis Neurology 29:556, 1979 GARLEPP MJ, MASTAGLIA FL: Inclusion body myositis J Neurol Neurosurg Psychiatry 60:251, 1996 GHERARDI R, BAUDRIMONT M, LIONNET F, et al: Skeletal muscle toxoplasmosis in patients with acquired immunode ciency syndrome: A clinical and pathological study Ann Neurol 32:535, 1992 GRIGGS RC, ASKANAS V, DIMAURO S, et al: Inclusion body myositis and myopathies Ann Neurol 38:705, 1995 GROSS B, OCHOA J: Trichinosis: A clinical report and histochemistry of muscle Muscle Nerve 2:394, 1979 HART MN, LINTHICUM DS, WALDSCHMIDT MM, et al: Experimental autoimmune in ammatory myopathy J Neuropathol Exp Neurol 46:511, 1987 HENGSTMAN GJD, VAN ENGELEN BGM, VAN EGBERTS WTMV, et al: Myositis-speci c autoantibodies: overview and recent developments Curr Op Neurol 13:476, 2001 KAKULAS BA, ADAMS RD: Diseases of Muscle: Pathological Foundations of Clinical Myology, 4th ed Philadelphia, Harper & Row, 1985 KASS EH, ANDRUS SB, ADAMS RD, et al: Toxoplasmosis in the human adult Arch Intern Med 89:759, 1952 KISSEL JT, MENDELL JR, RAMMOHEN KW: Microvascular deposition of complement membrane attack complex in dermatomyositis N Engl J Med 314:329, 1986.

5 When the process is complete, you will be informed via a dialog box, the contents of which will vary, depending on the OS you are using Choose to either exit the utility or defragment another disk

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